Guardians vs Orioles: Live Score, Lineup & Predictions (July 21, 2025)

On Jul 19, 2025

Guardians vs Orioles: Live Score, Lineup & Predictions (July 21, 2025)

July 21, 2025 • Progressive Field, Cleveland • Game time: 6:40 PM local

The much-anticipated **Guardians vs Orioles** showdown brings an electrifying clash at Progressive Field with thrilling implications—this matchup offers intense action, strong pitching duels, and postseason momentum. Fans and bettors can expect a riveting contest with strategic plays and key storylines.

🏟️ Live Score & Gamecast

Follow the live score below:

Live Gamecast: Guardians @ Orioles – ESPN

Head-to-Head (H2H): Guardians vs Orioles

This season, Cleveland and Baltimore have split the early series 2–2, while Baltimore leads the season H2H 3–1 :contentReference[oaicite:1]{index=1}.

Apr 15: Guardians 6–3 Orioles
Apr 16: Orioles 9–1 Guardians
Apr 17: Guardians 2–6 Orioles
Jul 21: Guardians vs Orioles (today)

Predicted Starting Lineups

Probable starters based on recent reports:

Cleveland Guardians

LF: Steven Kwan
3B: José Ramírez
SP: Shane Bieber
CF: Amed Rosario

Baltimore Orioles

CF: Cedric Mullins
3B: Gunnar Henderson
SP: Grayson Rodriguez
RF: Heston Kjerstad

Lineup Analysis & Predictions

Cleveland’s offense is steady with Kwan’s .313 average & .463 SLG, while Baltimore counters with Mullins (.308) and Henderson’s power. On the mound, Bieber (3.12 ERA, 1.09 WHIP) faces Rodriguez (2.79 ERA, 1.10 WHIP), promising a pitching duel :contentReference[oaicite:2]{index=2}.

Prediction: Guardians by a narrow margin, 4–3. ESPN analytics gives Cleveland ~55% edge :contentReference[oaicite:3]{index=3}.

Weather & Conditions

Forecast: warm and dry in Cleveland with no precipitation expected at game time.

📊 Key Matchups “Guardians vs Orioles”

Kwan vs Rodriguez: Kwan’s high OBP could pose problems for Rodriguez early.
Mullins vs Bieber: Mullins is currently the Orioles’ leading bat (.308, 17 RBI).
Bullpen depth: Guardians have had recent late-inning issues; Orioles’ bullpen remains untested.

Fan & Community Insights

Sports futures like betting odds favor the Guardians -1.5 on several picks sites :contentReference[oaicite:4]{index=4}.

FAQ: Guardians vs Orioles

What time is Guardians vs Orioles game?: The game starts at 6:40 PM local time on July 21, 2025.
Where to watch the game?: TV and streaming vary by region—check ESPN or local listings. Live Gamecast is on ESPN’s website.
Who has the pitching matchup?: Cleveland will likely start Shane Bieber; Baltimore counters with Grayson Rodriguez :contentReference[oaicite:5]{index=5}.
What is the recent H2H trend?: They’ve split early-season series and today’s game could tilt the balance.
Is weather a concern?: No—dry, warm conditions are expected at Progressive Field.